Dr. Leslie "Lee" Thompkins is a female Human who is the former lover of Typhuss James Halliwell, the widow of the late Mario Calvi and a former medical practitioner in the female ward of Arkham Asylum. She later becomes the medical examiner at the Gotham City SCIS Department, Typhuss's second ex-fiancée and the mother of their unborn child. However, Leslie loses the child and temporarily leaves Gotham City. She returns to Gotham City with her new fiancée, Mario, the son of Carmine Falcone. Lee later married Mario, 4 months later after meeting him. A year later after her marriage, Mario raped Lee while the two were in bed and he also tired to kill her, fortunately Typhuss arrived when he heard Lee's cries for help and shot Mario in the head, killing him and she took the blame for Mario's death, attempting to atone for her mistakes.
After Mario's death, she once again leaves Gotham because of the corruption that the city has brought, as well as to temporarily distance herself from Typhuss. However, she returns to Gotham once more, feeling guilty for letting the bomb go off, and has the task of healing the wounded in Cherry's place in the Narrows. After Barbara Kean shot Cherry, she became the new leader of the Narrows until she was tortured and thrown out on the street by Sofia Falcone. She shot Sofia in the head as a revenge and she became the leader of Narrows once again.